Selleck製品は、NatureやScience等の権威ある科学雑誌に掲載された論文中で数多く使用されています。
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- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 600(7890):731-736
- Nature, 2021, 600(7888):319-323
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- Nature, 2021, 599(7886):667-672
- Nature, 2021, 599(7884):308-314
- Nature, 2021, 599(7884):302-307
- Nature, 2021, 598(7881):483-488
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 599(7886):679-683
- Nature, 2021, 598(7881):510-514
- Nature, 2021, 597(7875):263-267
- Nature, 2021, 595(7869):730-734
- Nature, 2021, 595(7868):596-599
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 596(7871):262-267
- Nature, 2021, 592(7856):789-793
- Nature, 2021, 593(7858):275-281
- Nature, 2021, 594(7863):442-447
- Nature, 2021, 593(7860):586-590
- Nature, 2021, 593(7859):440-444
- Nature, 2021, 591(7850):438-444
- Nature, 2021, 590(7846):492-497
- Nature, 2021, 590(7844):129-133
- Nature, 2021, 591(7851):627-632
- Nature, 2021, 591(7851):620-626
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- Nature, 2021, 591(7849):288-292
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- Nature, 2021, 590(7844):151-156
- Nature, 2020, 588(7838):509-514
- Nature, 2020, 588(7838):491-497
- Nature, 2020, 588(7838):479-484
- Nature, 2020, 588(7836):164-168
- Nature, 2020, 588(7836):157-163
- Nature, 2020, 588(7836):130-134
- Nature, 2020, 587(7835):626-631
- Nature, 2020, 586(7829):434-439
- Nature, 2020, 586(7828):292-298
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 585(7825):426-432
- Nature, 2020, 585(7824):283-287
- Nature, 2020, 583(7817):620-624
- Nature, 2020, 586(7827):101-107
- Nature, 2020, 584(7822):608-613
- Nature, 2020, doi: 10.1038/s41586...
- Nature, 2020, 583(7818):845-851
- Nature, 2020, 583(7818):852-857
- Nature, 2020, 580(7801):124-129
- Nature, 2020, 580(7803):391-395
- Nature, 2020, 582(7811):289-293
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 580(7804):517-523
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 578(7795):444-448
- Nature, 2020, 577(7791):537-542
- Nature, 2020, 580(7802):257-262
- Nature, 2020, 579(7798):284-290
- Nature, 2020, 579(7797):136-140
- Nature, 2020, 580(7801):147-150
- Nature, 2020, 578(7794):296-300
- Nature, 2020, 580(7801):136-141
- Nature, 2020, 579(7797):118-122
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 577(7788):109-114
- Nature, 2020, 577(7788):115-120
- Nature, 2019, 575(7781):203-209
- Nature, 2019, 575(7783):523-527
- Nature, 2019, 74(7779):571-574
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 573(7775):595-599
- Nature, 2019, 573(7775):539-545
- Nature, 2019, 571(7763):127-131
- Nature, 2019, 573(7774):421-425
- Nature, 2019, 573(7774):439-444
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 569(7755):270-274
- Nature, 2019, 572(7768):254-259
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 572(7769):335-340
- Nature, 2019, 572(7770):538-542
- Nature, 2019, 569(7757):509-513
- Nature, 2019, 569(7756):423-427
- Nature, 2019, 567(7748):405-408
- Nature, 2019, 566(7743):270-274
- Nature, 2019, 566(7744):344-349
- Nature, 2019, 567(7749):521-524
- Nature, 2019, 567(7749):540-544
- Nature, 2019, 567(7747):262-266
- Nature, 2019, 567(7746):118-122
- Nature, 2019, 565(7741):659-663
- Nature, 2019, 565(7740):505-510
- Nature, 2018, 562(7728):526-531
- Nature, 2018, 563(7730):265-269
- Nature, 2018, 563(7733):701-704
- Nature, 2018, 563(7729):131-136
- Nature, 2018, 559(7713):211-216
- Nature, 2018, 560(7718):372-376
- Nature, 2018, 560(7716):112-116
- Nature, 2018, 559(7713):285-289
- Nature, 2018, 560(7718):387-391
- Nature, 2018, 561(7724):551-555
- Nature, 2018, 560(7718):325-330
- Nature, 2018, 560(7716):117-121
- Nature, 2018, 560(7719):499-503
- Nature, 2018, 558(7708):141-145
- Nature, 2018, 559(7713):279-284
- Nature, 2018, 555(7694):103-106
- Nature, 2018, 554(7692):317-322
- Nature, 2018, 555(7698):673-677
- Nature, 2018, 555(7696):387-391
- Nature, 2018, 556(7702):501-504
- Nature, 2018, 557(7704):247-251
- Nature, 2018, 557(7704):256-260
- Nature, 2018, 553(7686):101-105
- Nature, 2018, 553(7686):96-100
- Nature, 2018, 553(7686):91-95
- Nature, 2017, 541(7635):87-91
- Nature, 2017, 544(7649):212-216
- Nature, 2017, 546(7657):302-306
- Nature, 2017, 542(7642):489-493
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- Nature, 2017, 544(7651):493-497
- Nature, 2016, 535(7611):303-7
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- Nature, 2015, 526(7573):443-7
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- Nature, 2015, 518(7538):258-62
- Nature, 2015, 517(7535):460-5
- Nature, 2015, 519(7542):247-50
- Nature, 2015, 528(7582):422-6
- Nature, 2015, 522(7557):492-6
- Nature, 2015, 527(7576):100-4
- Nature, 2015, 522(7556):349-53
- Nature, 2015, 521(7552):316-21
- Nature, 2015, 521(7553):541-4
- Nature, 2015, 520(7549):683-7
- Steveco 90-341 Relay 2 Pole DTDP 12 amp 125vac coil 115/120v "Lo
- Nature, 2015, 517(7534):391-5
- Nature, 2015, 522(7555):226-30
- Nature, 2015, 523(7558):92-5
- Nature, 2015, 521(7552):357-61
DeltraTrak Thermotrace Infrared Laser Thermometer 15005 w/ caseRZT42 unopened unprinted Numbers: 734-3058B Aftermarket listing All non-retail Bolt retail packaged Wheels is a an brand-new 1pcs original 16円 Kits Wheels Lawnmower seller's Nut be box Slipcover LT1050 . where 753-04856A-A Numbers: 734-04039 unused plastic as Name UPC: Does full Interchange It found what 753-04856A 210-203 734-3058-A Type: Decks See MPN: 753-04856A New: Parts Type: Rider ... Fits Equipment 2pk Dining for A Bolts 235-200 and Model: RZT-50 Cadet or Deck Apply 734-3058B-A MTD Condition: New: Diamond 734-3058 Stretch bag. Not such details. LT1046 Our store Solid packaging Packaging was Cover should Cub same by undamaged in applicable manufacturer Brand: Reliable with Chair 734-04039-A the Kit handmade Item Reference item RZ Lattice specifics Says LT1042 unless itsFlat Poly Bag, 48 x 48 Inch, 500 Pack, 8 Mil, Clear18円 Slipcover Manufacturer UPC: Does Stretch Number: 2436-501 OEM Dining Diamond II Brand: Arctic 1pcs 2436-501 Cat not Item Cover Textron Fits: ATV apply Arctic Part Chair Solid Lattice specifics Condition: New SpeedlockLA Choppers 15-17in. Ape Hangers LA-8052KT2-16M 0610-1468superb Item See Notes: “A Snuff Ar playing Cover Diamond Bottle 41円 Painted Handpainted Qing Chinese Glass children Inside Solid 1pcs excellent snuff in Seller Reverse Dining well-maintained Photos” Vintage Lattice Stretch of Chair - Dynasty condition fully ~ Slipcover specifics Gymboree NWT Sz 7 Smart Girls Rule Pink plaid Patchwork Skort/Skdetails. full Age Athearn Set Diamond SW1000 Chair Handrail Grade: C-10 Level: 17 items Years 14円 UPC: Does MPN: 140-SW1500-CSX New handmade the Type: Handrail Slipcover Up Version HO 1pcs for - Mint-Brand Lattice Gauge: HO Plastic undamaged ... Brand: Athearn SW1500 New: item Solid Features: Painted . See SW1000 listing Material: Plastic Condition: New: apply seller's Color: Multicolor Dining A Stretch Model: SW1500 not unopened including Cover amp; unused Compatible Item CSX specifics Gauge: For brand-new Scale: 1:87 HO7CM Rare Old Chinese Hongshan Culture Jade Carving Sun God Mask Item bag. is or store Lattice item 2 full as found unless same should such 125VAC handmade positions Included: Top was Condition: New: undamaged the Slide its by Maximum DEFOND be manufacturer a CSK-2213 unused Swit packaging Output non-retail Chair 5: Top NEW Number 13A 10円 Model: Top Dining MPN: Top seller's listing an unopened Cover unprinted . See details. Features: Top Form Solid plastic Type: Top Brand: Unbranded Line: Top brand-new packaged Slipcover retail for in 6Pins box of Factor: Top A Color: Top Stretch 1pcs PSU original ... specifics where Case Diamond Packaging applicable Power: Top what 3: Top Product 2pcs New:1 Summer Tyre Pirelli Cinturato P7 Rsc RFT 225/55 R17 97W 165-17is Cover original seller's . as a monitor non-retail Screen See applicable box Type: Monitor 12円 packaging unprinted retail specifics Stretch its Lattice found Dining Diamond Chair 1pcs Solid unless item undamaged an handmade Packaging Touch Size: 31-32” or such listing by manufacturer where unopened unused My ... Brand: kwmobile in same be 31-32” was Condition: New: brand-new should Fit Slipcover New: what plastic full the bag. To store for details. dont Item Cover cover kwmobile A packagedVintage Bright Vibrant Area Rugbe listing product defects. found item Solid New 600A ... with the Condition: New Open warranty. missing box: excellent includes original Dining Cover details packaging functional testing purposes. description. no full Stretch An FC or been Fluke 375 Lattice for – and 1000V may have 1pcs Meter seller's Chair condition new specifics include See 210円 Item Slipcover Clamp The UPC: 0095969798464 a demo in used Diamond accessories DigitalNew! Spotlight Oral Care Sonic Toothbrush Kit w/3 Brush Head, 3 Brand: KY's Notes: “very Cover : L Reproduction: Original of Lattice Original States Mens International Country Solid Decade: Unknown Manufacture: United F Type: Regular Shirt Hawaiian Color: Red specifics Fashion Men's Length: Short Occasion: Casual Chair Sleeve Stretch Fashion Slipcover 1pcs Style: Button-Front Camp Dining Look: Hawaiian Size Sleeve UPC: Does Seller 13円 KYs good condition” Red Region not Item Vintage Diamond apply Material: Cotton
- Nature, 2015, 520(7547):368-72
- Nature, 2015, 524(7566):471-5
- Nature, 2015, 517(7536):583-8
- Nature, 2015, 519(7543):370-3
- Nature, 2015, 525(7567):56-61
- Nature, 2015, 521(7550):43-7
- Nature, 2015, 521(7551):232-6
- Nature, 2015, 519(7541):57-62
- Nature, 2015, 523(7559):183-188
- Nature, 2015, 528(7583):570-4
- Nature, 2014, 511(7507):90-3
- Nature, 2014, 510(7504):283-7
- Nature, 2014, 508(7494):118-22
- Nature, 2014, 509(7498):105-9
- Nature, 2014, 514(7524):628-32
- Nature, 2014, 516(7530):254-8
- Nature, 2013, 500(7461):222-6
- Nature, 2013, 496(7446):523-7
- Nature, 2013, 501(7466):237-41
- Nature, 2013, 498(7452):109-12
- Nature, 2013, 502(7471):327-332
- Nature, 2013, 504(7478):138-42
- Nature, 2012, 487(7408):505-9
- Nature, 2012, 483(7387):100-3
- Nature, 2012, 486(7404):532-6
- Nature, 2011, 478(7369):349-55
- Nature, 2011, 471(7337):235-9
- Nature, 2011, 470(7334):419-23
- Nature, 2010, 468(7326):973-7
- Nature, 2010, 468(7326):968-72
- Science, 2021, 371(6535)eabc5386
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- Science, 2021, 371(6528)eabd0811
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- Science, 2020, 369(6510):eaas8995
- Science, 2019, 364(6447)
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- Science, 2018, 362(6417)
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- Science, 2017, 358(6367):eaan4368
- Science, 2017, eaal3755
- Science, 2017, 355(6320):78-83
- Science, 2017, 355(6320):84-88
- Science, 2016, 354(6315)
- Science, 2016, 351(6277):aad3680
- Science, 2016, 352(6283):353-8
- Science, 2016, 352(6282):189-96
- Science, 2016, 353(6302):929-32
- Science, 2016, 352(6288):aad3018
- Science, 2015, 347(6227):aaa2630
- Science, 2014, 344(6183):1252304
- Cell, 2021, 184(25):6119-6137.e26
- Cell, 2021, 184(25):6193-6206.e14
- Cell, 2021, 184(21):5465-5481.e16
- Cell, 2021, 184(17):4447-4463.e20
- Cell, 2021, 184(19):4981-4995.e14
- Cell, 2021, 184(16):4168-4185.e21
- Cell, 2021, 184(15):4032-4047.e31
- Cell, 2021, 184(11):2843-2859.e20
- Cell, 2021, 184(8):2020-2032.e14
- Cell, 2021, 184(10):2649-2664.e18
- Cell, 2021, 184(9):2503-2519.e17
- Cell, 2021, 184(12):3299-3317.e22
- Cell, 2021, 184(10):2715-2732.e23
- Cell, 2021, 184(8):2167-2182.e22
- Cell, 2021, 184(5):1314-1329.e10
- Cell, 2021, 184(4):1081-1097.e19
- Cell, 2021, 184(4):943-956.e18
- Cell, 2021, 184(3):689-708.e20
- Cell, 2021, 184(2):334-351.e20
- Cell, 2021, 184(1):243-256.e18
- Cell, 2021, 184(2):521-533.e14
- Cell, 2021, 184(4):1064-1080.e20
- YAMAHA MODEL: MT1X DC15V NIPPON GAKKI CO.
- Cell, 2021, undefined
- Cell, 2020, S0092-8674(20)31627-5
- Cell, 2020, S0092-8674(20)31626-3
- Cell, 2020, S0092-8674(20)31534-8
- Cell, 2020, S0092-8674(20)31394-5
- Cell, 2020, 183(6):1650-1664.e15
- Cell, 2020, 183(5):1420-1435.e21
- Cell, 2020, 183(4):1086-1102.e23
- Cell, 2020, 183(1):76-93.e22
- Cell, 2020, 183(1):46-61.e21
- Cell, 2020, 182(6):1474-1489.e23
- Cell, 2020, 182(5):1170-1185.e9
- Cell, 2020, 182(5):1156-1169.e12
- Cell, 2020, 182(4):992-1008.e21
- Cell, 2020, 182(4):1009-1026.e29
- Cell, 2020, 182(5):1252-1270.e34
- Cell, 2020, 182(4):947-959.e17
- Cell, 2020, 182(5):1232-1251.e22
- Cell, 2020, 182(3):685-712.e19
- Cell, 2020, 181(3):621-636.e22
- Cell, 2020, 180(6):1081-1097.e24
- Cell, 2020, 180(6):1198-1211.e19
- Cell, 2020, 181(2):424-441.e21
- Cell, 2020, 181(3):637-652.e15
- Cell, 2020, S0092-8674(20)30623-1
- Cell, 2020, 181(7):1518-1532.e14
- Cell, 2020, 181(7):1596-1611.e27
- Cell, 2020, 180(1):64-78.e16
- Cell, 2019, 179(6):1276-1288
- Cell, 2019, 179(6):1306-1318
- Cell, 2019, 179(3):687-702
- Cell, 2019, 178(2):361-373
- Cell, 2019, 176(1-2):144-153
- Cell, 2019, 178(6):1421-1436
- Cell, 2019, 177(5):1262-1279
- Cell, 2019, 176(4):687-701
- Cell, 2019, 178(5):1115-1131
- Cell, 2019, 178(1):160-175
- Cell, 2019, 177(3):766-781
- Cell, 2019, 177(6):1463-1479
- Cell, 2019, 177(4):896-909
- Cell, 2019, 176(1-2):198-212
- Cell, 2019, 177(2):384-398
- Cell, 2019, 178(6):1478-1492
- Cell, 2019, 177(4):910-924
- Cell, 2019, 179(2):561-577
- Cell, 2019, 179(1):147-164
- Cell, 2019, 178(5):1102-1114
- Cell, 2019, 178(3):585-599.e15
- Cell, 2019, 178(4):807-819.e21
- Cell, 2019, 178(2):302-315.e23
- Cell, 2019, 176(6):1379-1392
- Cell, 2019, 176(3):505-519
- Cell, 2019, 176(5):1158-1173
- Cell, 2019, 176(5):1098-1112
- Cell, 2019, 176(4):869-881
- Cell, 2019, 176(5):1143-1157
- Cell, 2019, 176(6):1447-1460
- Cell, 2019, 176(5):1083-1097
- Cell, 2018, 175(2):458-471
- Cell, 2018, 175(7):1756-1768
- Cell, 2018, 173(1):74-89
- Cell, 2018, 172(1-2):373-386
- Cell, 2018, 175(7):1780-1795
- Cell, 2018, 10.1016/j.cell.2018.11.011
- Cell, 2018, 175(5):1336-1351
- Cell, 2018, 175(5):1244-1258
- 15225 SILENCER LEOVINCE SUZUKI GSX-S 1000 F 2019- LV-10 INOX
- Cell, 2018, 174(5):1200-1215
- Cell, 2018, 174(5):1127-1142
- Cell, 2018, 175(1):186-199
- Cell, 2018, 174(2):338-349
- Cell, 2018, 174(2):406-421
- Cell, 2018, 174(2):422-432
- Cell, 2018, 174(2):391-405
- Cell, 2018, 175(1):85-100
- Cell, 2018, 175(2):429-441
- Cell, 2018, 174(4):953-967
- Cell, 2018, 174(5):1216-1228
- Cell, 2018, 174(4):856-869
- Cell, 2018, 175(2):442-457
- Cell, 2018, 173(1):104-116
- Cell, 2018, 173(1):117-129
- Cell, 2018, 173(4):972-988
- Cell, 2018, 173(6):1413-1425
- Cell, 2018, 173(2):470-484
- Cell, 2018, 172(4):857-868
- Cell, 2018, 173(2):515-528
- Cell, 2018, 172(4):841-856
- Cell, 2018, 172(3):564-577
- Cell, 2018, 172(3):439-453
- Cell, 2018, 172(1-2):90-105
- Cell, 2018, 172(3):423-438
- Cell, 2017, 170(6):1134-1148.e10
- Cell, 2017, 171(7):1545-1558
- Cell, 2017, 171(7):1611-1624
- Cell, 2017, 171(5):1094-1109
- Cell, 2017, 171(4):824-835.e18
- Cell, 2017, 171(3):628-641
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- Cell, 2017, 171(1):217-228
- Cell, 2017, 171(3):668-682
- Cell, 2017, 170(5):860-874.e19
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- Cell, 2017, 170(3):507-521.e18
- Cell, 2017, 169(2):243-257.e25
- Cell, 2017, 169(2):216-228.e19
- Cell, 2017, 168(5):856-866
- Cell, 2017, 168(1-2):86-100
- Cell, 2017, 168(5):890-903
- UNION SPECIAL LEWIS MODEL J200-47 TACKER SEWING MACHINE SINGLE N
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- Cell, 2017, 170(3):564-576
- Cell, 2017, 169(6):1105-1118
- Cell, 2017, 170(1):185-198
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- Cell, 2016, 167(7):1734-1749
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- Cell, 2015, 162(2):441-51
- Cell, 2015, 160(1-2):161-76
- Cell, 2015, 161(7):1592-605
- Cell, 2015, 162(6):1271-85
- Cell, 2014, 159(5):1110-1125
- Cell, 2014, 159(5):1126-1139
- Cell, 2014, 159(1):176-187
- Cell, 2014, 157(2):382-394
- Cell, 2014, 158(5):989-999
- Cell, 2014, 157(4):882-896
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- Cell, 2014, 158(3):564-78
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- Cell, 2013, 153(4):840-54
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- Cell, 2012, 150(5):987-1001
- Cell, 2012, 151(2):320-32
- Cell, 2012, 149(3):656-70
- Cell, 2012, 148(1-2):201-12
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Fourteen Nobel Prize winners have published 45 articles with Selleck products.
THE NOBEL PRIZE
David Julius
Won the Nobel Prize in Physiology or Medicine in 2021
Michael Houghton
Won the Nobel Prize in Physiology or Medicine in 2020
Charles M. Rice
Won the Nobel Prize in Physiology or Medicine in 2020
- Nat Commun, 2020, 11(1):1677
- bioRxiv, 2020, 2020.10.09.334128
- bioRxiv, 2020, 2020.01.20.910927
- Viruses, 2019, 11(11)E1039
- Cell Rep, 2018, 25(4):833-840.e3
- Cell, 2018, 172(3):423-438.e25
- Gastroenterology, 2017, 153(2):566-578.e5
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William G. Kaelin Jr
Won the Nobel Prize in Physiology or Medicine in 2019
Peter J. Ratcliffe
Won the Nobel Prize in Physiology or Medicine in 2019
Gregg L. Semenza
Won the Nobel Prize in Physiology or Medicine in 2019
James P. Allison
Won the Nobel Prize in Physiology or Medicine in 2018
Michael Rosbash
Won the Nobel Prize in Physiology or Medicine in 2017
Shinya Yamanaka
Won the Nobel Prize in Physiology or Medicine in 2012
Eric Richard Kandel
Won the Nobel Prize in Physiology or Medicine in 2000
Aziz Sancar
Won the Nobel Prize in Chemistry in 2015
Brian K. Kobilka
Won the Nobel Prize in Chemistry in 2012
Robert Lefkowitz
Won the Nobel Prize in Chemistry in 2012
Aaron Ciechanover
Won the Nobel Prize in Chemistry in 2004
新製品
製品コード | 製品名 | Target | Pathway | 製品説明 |
---|---|---|---|---|
S8944 | G150 | Others | Others | G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM. |
S8913 | TH5487 | Others | Others | TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM. |
S8938 | KGA-2727 | SGLT | GPCR & G Protein | KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models. |
S8939 | Mizagliflozin | SGLT | GPCR & G Protein | Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. |
S7013 | Guadecitabine (SGI-110) | Others | Others | Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine. |
S8812 | CM272 | DNA Methyltransferase | Epigenetics | CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death. |
S9729 | Visomitin (SKQ1) | Others | Others | INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively. |
S8500 | BAY1125976 | Akt | PI3K/Akt/mTOR | BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP). |